Product Design and Finite Element Analysis
Stress concentration lowered at junction of two different Materials
Vascular diseases are the leading cause of death in developed countries. Flow limiting disorders in iliac vessels, femoral, renal, carotid and coronary arteries are being treated by stenting. But one-third of Stenting fail due to restenosis.
The factors influencing the response of an arterial wall to stenting after angioplasty are complicated and not well understood. After inserting stent into vessels, causes of restenosis may be related to the mechanical conditions in the stented artery. Stenting may influence blood flow patterns - Vortex formation that may lead to platelet activation, and flow stagnation that may be related to platelet adhesion through increased near-wall particle residence time. And vessel wall stresses in a way that encourages restenosis. Endovascular applications, endovascular metallic stents have had mixed success in preventing late post-angioplasty restenosis. Restenosis occurs within several weeks to one year after uncomplicated PTA and is due to neointimal hyperplasia. Addition of systemic approaches including anticoagulats, anti-platel agents, anti spasm therapy, anti-inflammatory drugs and lipid-lowering agents have not lowered the high rate of lesion recurrence.
Optimized Stress-Concentration at the junction of two different materials (Hard Nickel and Titanium composite, and soft Artery Tissue) approximately 33%. This information will be used for next generation STENT design.
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